In Australia more than half of the population (59%) are thought to have had at least one personal stressor in the past year. In addition, almost half of the Australian population have experienced problems with sleep quality. (1,2) These stressors incur a considerable social, financial and economic cost to self and society, with stress estimated to cost Australians over 13 billion each year. (1) Implementing relaxation techniques such as meditation, deep breathing, and progressive muscle relaxation, combined with regular exercise and a balanced diet, can effectively improve sleep quality and reduce stress. (3)

In addition to healthy lifestyle routines, the Life-Space Neurobiotic formulation can assist with sleep quality and stress relief through the key probiotic strain Bifidobacterium longum 1714 (Probiobrain™). This probiotic strain has been shown to support the gut-brain axis by improving stress tolerance, mental fatigue, and sleep quality. (4,5) In addition, the probiotic Bifidobacterium animalis ssp. lactis BB-12 has been included to support beneficial intestinal flora, maintain healthy gastrointestinal function and to support healthy immune system function. (6)

In addition to the probiotics in this formulation, L-theanine (AlphaWave®) has been included to further support mental health and wellbeing. L-theanine, which is a naturally occurring amino acid found predominantly in tea leaves, has been shown to relieve stress symptoms and improving cognition. (7,8)

Scientific research has shown that L-theanine supports mental wellbeing through several key mechanisms:

  • Stress Response Management: L-theanine helps to maintain the body's physiological response to stressful situation, helping us adapt to mental stress. (9–11)
  • Supports cognitive function: Research shows L-theanine can support cognition by supporting verbal and letter fluency, revealing an improvement in mental clarity. (9)
  • Support memory and mental recall: L-theanine has been shown to improve working memory and reaction times (12)

In summary, the Life-Space Neurobiotic formula uses Bifidobacterium longum 1714 (Probiobrain™) and L-theanine (AlphaWave®) to support the gut-brain connection while also supporting beneficial intestinal flora using the strain Bifidobacterium animalis ssp. lactis BB-12. This formulation supports gut health and cognitive performance while relieving stress, improving sleep quality, and reducing mental fatigue, offering positive support for intestinal health and mental wellbeing.

 

Direction for use

Take 1 capsule daily for stress and sleep benefits, 2 capsules daily for cognitive benefits, or as directed by your health professional. Always read the label and follow the directions for use.

 

 

 

References

1. Australian Institute of Health and Welfare [Internet]. 2025 [cited 2025 Sep 3]. Stress and trauma - Mental health. Available from: https://www.aihw.gov.au/mental-health/topic-areas/health-wellbeing/stress-and-trauma

2. Australian Institute of Health and Welfare [Internet]. 2021 [cited 2025 Sep 3]. Sleep problems as a risk factor for chronic conditions, Summary. Available from: https://www.aihw.gov.au/reports/risk-factors/sleep-problems-as-a-risk-factor/summary

3. Mayo Clinic [Internet]. [cited 2025 Sep 11]. Relaxation techniques: Try these steps to lower stress. Available from: https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/relaxation-technique/art-20045368

4. Wang H, Braun C, Murphy EF, Enck P. Bifidobacterium longum 1714TM Strain Modulates Brain Activity of Healthy Volunteers During Social Stress. Am J Gastroenterol. 2019 Jul;114(7):1152–62.

5. Patterson E, Tan HTT, Groeger D, Andrews M, Buckley M, Murphy EF, et al. Bifidobacterium longum 1714 improves sleep quality and aspects of well-being in healthy adults: a randomized, double-blind, placebo-controlled clinical trial. Sci Rep. 2024 Feb 14;14:3725.

6. Jungersen M, Wind A, Johansen E, Christensen JE, Stuer-Lauridsen B, Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®. Microorganisms. 2014 Mar 28;2(2):92–110.

7. Dashwood R, Visioli F. l-theanine: From tea leaf to trending supplement – does the science match the hype for brain health and relaxation? Nutrition Research. 2025 Feb 1;134:39–48.

8. AlphaWave® - L-Theanine [Internet]. Ethical Naturals, Inc. (ENI). [cited 2025 Sep 10]. Available from: https://ethicalnaturals.com/products-manufacturing-services/alphawave-l-theanine/

9. Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362.

10. Unno K, Tanida N, Ishii N, Yamamoto H, Iguchi K, Hoshino M, et al. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress. Pharmacol Biochem Behav. 2013 Oct;111:128–35.

11. Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39–45.

12. Baba Y, Inagaki S, Nakagawa S, Kaneko T, Kobayashi M, Takihara T. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study. J Med Food. 2021 Apr;24(4):333–41.

 

 

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